Catalog #: 213-ILB
126 Citations 10 Reviews Datasheet / COA / SDS
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All IL-13 Proteins and Enzymes
Product Details
Citations (126)
FAQs
Reviews (10)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas
Recombinant Human IL-13 Protein Summary
Product Specifications
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 0.5-2.5 ng/mL.
Source
E. coli-derived human IL-13 protein
Gly21-Asn132
Accession #
N-terminal Sequence
Analysis
Gly21
Predicted Molecular Mass
12.3 kDa
SDS-PAGE
9 kDa, reducing conditions
Product Datasheets
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213-ILB (with carrier)
Product Datasheet
COA
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
213-ILB
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 100 μg/mL in PBS containing at least 0.1% human or bovine serum albumin. |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
213-ILB/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 100 μg/mL in PBS. |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Scientific Data
SEC-MALS View Larger
Recombinant Human IL-13 Protein (Catalog # 213-ILB) has a molecular weight (MW) of 12.0 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.
Bioactivity View Larger
Recombinant human IL-13 (213-ILB) stimulates proliferation in the TF-1 human erythroleukemic cell line. The ED50 for this effect is 0.5-2.5 ng/mL.
Reconstitution Calculator
Reconstitution Calculator
Background: IL-13
Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells (1‑3). Mature human IL-13 shares approximately 58%amino acid sequence identity with mouse and rat IL-13. Despite the low hom*ology, it exhibits cross‑species activity between human, mouse, and rat (4). IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. On B cells, it promotes cellular activation, immunoglobulin class switching to IgE, and the up‑regulation of CD23/Fc epsilon RII (1,5). IL-13 binds with low affinity to the transmembrane IL-13 R alpha 1 which then forms a signaling complex with the transmembrane IL-4 R alpha (6‑8). This high affinity receptor complex also functions as the type 2 IL-4 receptor (6,7). IL‑13R alpha 2 inhibits responses to both IL-13 and IL-4. It binds IL-13 with high affinity (9, 10) and prevents IL-13 from signaling through the IL-13 R alpha 1/IL-4 R alpha complex (11,12). It also blocks signaling through IL-4-occupied IL-13 R alpha 1/IL-4 R alpha receptor complexes (12, 13). In addition, IL-13-bound IL-13 R alpha 2 can directly promote tumor cell invasiveness and the development of tissue fibrosis (14‑16).
- Saggini, A. et al. (2011) Int. J. Immunopathol. Pharmacol. 24:305.
- Gallo, E. et al. (2012) Eur. J. Immunol. 42:2322.
- Liang, H.E. et al. (2012) Nat. Immunol. 13:58.
- Ruetten, H. and C. Thiemermann (1997) Shock 8:409.
- McKenzie, A.N. et al. (1993) Proc. Natl. Acad. Sci. USA 90:3735.
- Aman, M.J. et al. (1996) J. Biol. Chem. 271:29265.
- Zurawski, S.M. et al. (1995) J. Biol. Chem. 270:13869.
- Andrews, A.L. et al. (2002) J. Biol. Chem. 277:46073.
- Chen, W. et al. (2009) J. Immunol. 183:7870.
- Daines, M.O. et al. (2007) J. Allergy Clin. Immunol. 119:375.
- Kasaian, M.T. et al. (2011) J. Immunol. 187:561.
- Andrews, A.-L. et al. (2006) J. Allergy Clin. Immunol. 118:858.
- Rahaman, S.O. et al. (2002) Cancer Res. 62:1103.
- Fujisawa, T. et al. (2009) Cancer Res. 69:8678.
- Fujisawa, T. et al. (2011) Int. J. Cancer 131:344.
- Fichtner-Feigl, S. et al. (2006) Nat. Med. 12:99.
Long Name
Interleukin 13
Entrez Gene IDs
3596 (Human); 16163 (Mouse); 116553 (Rat); 574325 (Primate)
Alternate Names
ALRHMGC116789; BHR1interleukin-13; IL13; IL-13; IL-13MGC116788; interleukin 13; MGC116786; NC30; P600
Related Research Areas
- Cytokines and Receptors in Allergy and Asthma
- Cytokines and Receptors in Angiogenesis
- Cytokines and Receptors in Tfh Cell Differentiation and Function
- gamma delta T Cells
- Group 2 ILCs
- Microglia Activation Markers
- Myeloid-derived Suppressor Cells (MDSC)
- Natural Killer T (NKT) Cells
- Search Cytokine and Growth Factor Products
- T Cell Cytokine Signaling
- Th2 Cells
- Th22 Cells
Citations for Recombinant Human IL-13 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
126 Citations: Showing 1 - 10
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- Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface
Authors: Liu, J;Deng, Y;Wang, A;Liu, B;Zhou, X;Yin, T;Wang, Y;Tang, T;Qiu, Y;Chen, J;Yang, J;
Cell death & disease
Species: Human
Sample Types: Transduced Whole Cells, Whole Cells
Applications: Bioassay - Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway-mediated fibroblast activation
Authors: Shuangshuang, H;Mengmeng, S;Lan, Z;Fang, Z;Yu, L;
Journal of ethnopharmacology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Influence of Macrophages on Vascular Invasion of Inflammatory Breast Cancer Emboli Measured Using an In Vitro Microfluidic Multi-Cellular Platform
Authors: Gadde, M;Mehrabi-Dehdezi, M;Debeb, BG;Woodward, WA;Rylander, MN;
Cancers
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Comprehensive analysis of E47?like factors and verification of ELF4 in clear cell renal cell carcinoma
Authors: Lu, J;Zhang, Q;Mo, L;Chen, W;Mao, L;
Oncology letters
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - CellSNAP: A fast, accurate algorithm for 3D cell segmentation in quantitative phase imaging
Authors: Raj, P;Paidi, S;Conway, L;Chatterjee, A;Barman, I;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Enhanced powder dispersion of dual-excipient spray-dried powder formulations of a monoclonal antibody and its fragment for local treatment of severe asthma
Authors: Pan, HW;Guo, J;Zhu, L;Leung, SWS;Zhang, C;Lam, JKW;
International journal of pharmaceutics
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - TRAIP serves as a potential prognostic biomarker and correlates with immune infiltrates in lung adenocarcinoma
Authors: Jing, Y;Mao, Z;Zhu, J;Ma, X;Liu, H;Chen, F;
International immunopharmacology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Targeting Glioblastoma-Associated Macrophages for Photodynamic Therapy Using AGuIX�-Design Nanoparticles
Authors: L Lerouge, M Gries, A Chateau, J Daouk, F Lux, P Rocchi, J Cedervall, AK Olsson, O Tillement, C Frochot, S Acherar, N Thomas, M Barberi-He
Pharmaceutics, 2023-03-20;15(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Light-sheet laser speckle imaging for cilia motility assessment
Authors: K Long, J Liu, S Shen, M Thong, D Wang, N Chen
Computational and structural biotechnology journal, 2023-02-20;21(0):1661-1669.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Induction of type II collagen expression in M2 macrophages derived from peripheral blood mononuclear cells
Authors: FH Wang, CY Hsieh, CI Shen, CH Chuang, YH Chung, CC Kuo, KD Lee, CL Lin, HL Su
Scientific Reports, 2022-12-15;12(1):21663.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Decreased Innate Migration of Pro-Inflammatory M1 Macrophages through the Mesothelial Membrane Is Affected by Ceramide Kinase and Ceramide 1-P
Authors: CW Ku, J Yang, HY Tan, JKY Chan, YH Lee
International Journal of Molecular Sciences, 2022-12-15;23(24):.
Species: Human
Sample Types: Whole Cells
Applications: Polarization - EMR1/ADGRE1 Expression in Cancer Cells Upregulated by Tumor-Associated Macrophages Is Related to Poor Prognosis in Colorectal Cancer
Authors: R Akter, K Kim, HY Kwon, Y Kim, YW Eom, HM Cho, MY Cho
Biomedicines, 2022-12-02;10(12):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance
Authors: A Mentxaka, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, G Neira, V Valentí, R Moncada, C Silva, X Unamuno, JA Cienfuegos, J Escalada, G Frühbeck, V Catalán
Nutrients, 2022-10-18;14(20):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo
Authors: F Real, A Zhu, B Huang, A Belmellat, A Sennepin, T Vogl, C Ransy, M Revol, R Arrigucci, A Lombès, J Roth, ML Gennaro, F Bouillaud, S Cristofari, M Bomsel
Nature Communications, 2022-10-11;13(1):5956.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target
Authors: H Cho, HY Kwon, A Sharma, SH Lee, X Liu, N Miyamoto, JJ Kim, SH Im, NY Kang, YT Chang
Nature Communications, 2022-10-10;13(1):5974.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease
Authors: P Pavlidis, A Tsakmaki, A Treveil, K Li, D Cozzetto, F Yang, U Niazi, BH Hayee, M Saqi, J Friedman, T Korcsmaros, G Bewick, N Powell
Cell Reports, 2022-09-27;40(13):111439.
Species: Human
Sample Types: Organoid
Applications: Bioassay - Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins
Authors: V Catalán, P Domench, J Gómez-Ambr, B Ramírez, S Becerril, A Mentxaka, A Rodríguez, V Valentí, R Moncada, J Baixauli, C Silva, J Escalada, G Frühbeck
International Journal of Molecular Sciences, 2022-08-17;23(16):.
Species: Human
Sample Types: Whole Cells
Applications: Stimulation - Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid Extract
Authors: S Segarra, T Naiken, J Garnier, V Hamon, N Coussay, FX Bernard
Oncogene, 2022-06-27;9(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - CD206+ tumor-associated macrophages cross-present tumor antigen and drive anti-tumor immunity
Authors: M Modak, AK Mattes, D Reiss, W Skronska-W, R Langlois, N Sabarth, R Konopitzky, F Ramírez, K Lehr, T Mayr, D Kind, C Viollet, LK Swee, J Petschenka, KC El Kasmi, E Noessner, K Kitt, S Pflanz
JCI Insight, 2022-06-08;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Preferential stimulation of melanocytes by M2 macrophages to produce melanin through vascular endothelial growth factor
Authors: H Han, Y Kim, H Mo, SH Choi, K Lee, YA Rim, JH Ju
Scientific Reports, 2022-04-19;12(1):6416.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Elevated Serum Leptin Levels in Patients With Eosinophilic Chronic Rhinosinusitis
Authors: Y Imoto, S Ueki, Y Kato, K Yoshida, T Morikawa, Y Kimura, M Kidoguchi, T Tsutsumiuc, K Koyama, N Adachi, Y Ito, K Ogi, M Sakash*ta, T Yamada, RP Schleimer, T Takabayash, S Fujieda
Frontiers in Pharmacology, 2022-01-03;12(0):793607.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Development of a potent high-affinity human therapeutic antibody via novel application of Recombination Signal Sequence (RSS)-based Affinity Maturation
Authors: A Kielczewsk, I D'Angelo, MS Amador, T Wang, A Sudom, X Min, P Rathanaswa, C Pigott, IN Foltz
The Journal of Biological Chemistry, 2021-12-29;0(0):101533.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
Authors: E Kim, H Um, J Park, JW Jung, JE Kim, H Lee, EA Shin, Y Pinanga, H Lee, SH Nam, JW Lee
Cell Reports, 2021-11-16;37(7):110018.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Bee Venom Prevents Mucin 5AC Production through Inhibition of AKT and SPDEF Activation in Airway Epithelia Cells
Authors: S Kim, HW Kim, SH Chang, KH Leem, HJ Park
Toxins, 2021-11-01;13(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris
Authors: S Shao, J Chen, WR Swindell, LC Tsoi, X Xing, F Ma, R Uppala, MK Sarkar, O Plazyo, AC Billi, R Wasikowski, KM Smith, P Honore, VE Scott, E Maverakis, JM Kahlenberg, G Wang, NL Ward, PW Harms, JE Gudjonsson
JCI Insight, 2021-10-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Macrophage Polarization Related to Crystal Phases of Calcium Phosphate Biomaterials
Authors: L Xiao, Y Shiwaku, R Hamai, K Tsuchiya, K Sasaki, O Suzuki
International Journal of Molecular Sciences, 2021-10-19;22(20):.
Species: Human
Sample Types: Whole Cells
Applications: Polarization - Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis
Authors: A Kuzumi, A Yoshizaki, KM Matsuda, H Kotani, Y Norimatsu, M f*ckayama, S Ebata, T f*ckasawa, A Yoshizaki-, Y Asano, K Morikawa, Y Kazoe, K Mawatari, T Kitamori, S Sato
Nature Communications, 2021-10-12;12(1):5947.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - IL-13 acts directly on gastric epithelial cells to promote metaplasia development during chronic gastritis
Authors: CN Noto, SG Hoft, KA Bockerstet, NM Jackson, EL Ford, LS Vest, RJ DiPaolo
Cellular and Molecular Gastroenterology and Hepatology, 2021-09-26;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay - Decreased Levels of Microfibril-Associated Glycoprotein (MAGP)-1 in Patients with Colon Cancer and Obesity Are Associated with Changes in Extracellular Matrix Remodelling
Authors: I Gómez de S, P Ahechu, J Gómez-Ambr, A Rodríguez, B Ramírez, S Becerril, X Unamuno, A Mentxaka, J Baixauli, V Valentí, R Moncada, C Silva, G Frühbeck, V Catalán
International Journal of Molecular Sciences, 2021-08-06;22(16):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Remodeling of bronchial epithelium caused by asthmatic inflammation affects its response to rhinovirus infection
Authors: B Jakiela, A Rebane, J Soja, S Bazan-Soch, A Laanesoo, H Plutecka, M Surmiak, M Sanak, K Sladek, G Bochenek
Scientific Reports, 2021-06-17;11(1):12821.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels
Authors: X Huang, T Oshima, T Tomita, H f*ckui, H Miwa
Biology, 2021-03-09;10(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Butyrate and Propionate Restore the Cytokine and House Dust Mite Compromised Barrier Function of Human Bronchial Airway Epithelial Cells
Authors: LB Richards, M Li, G Folkerts, PAJ Henricks, J Garssen, BCAM van Esch
International Journal of Molecular Sciences, 2020-12-23;22(1):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - circARRDC3 contributes to interleukin?13?induced inflammatory cytokine and mucus production in nasal epithelial cells via the miR?375/KLF4 axis
Authors: T Wang, P Wang, D Chen, Z Xu, L Yang
Molecular Medicine Reports, 2020-12-14;23(2):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients
Authors: I Hwang, JW Kim, K Ylaya, EJ Chung, H Kitano, C Perry, J Hanaoka, J f*ckuoka, JY Chung, SM Hewitt
J Transl Med, 2020-11-23;18(1):443.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/I&kappaB&alpha pathway
Authors: HK Min, JY Won, BM Kim, KA Lee, SJ Lee, SH Lee, HR Kim, KW Kim
Arthritis Research & Therapy, 2020-09-23;22(1):222.
Species: Human
Sample Types: Reference Standard
- The use of patient-derived breast tissue explants to study macrophage polarization and the effects of environmental chemical exposure
Authors: KJ Gregory, SM Morin, A Kubosiak, J Ser-Dolans, B Schalet, DJ Jerry, SS Schneider
Immunol. Cell Biol., 2020-09-09;0(0):.
Species: Human
Sample Types: Whole Cell
Applications: Cell Culture - IL13Ralpha1 protects against rheumatoid arthritis by combating the apoptotic resistance of fibroblast-like synoviocytes
Authors: X Yang, Q Guo, T Feng, Q Lu, L Ge, J Pan, K Bi, L Qiao, L Tian, T Xie, C Yao, G Song, L Wang
Arthritis Res. Ther., 2020-08-08;22(1):184.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Ozone-derived oxysterols impair lung macrophage phagocytosis via adduction of some phagocytosis receptors
Authors: PF Duffney, HH Kim, NA Porter, I Jaspers
J. Biol. Chem., 2020-07-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - Anti-Cancer Activity of Acriflavine as Metabolic Inhibitor of OXPHOS in Pancreas Cancer Xenografts
Authors: A Bulle, J Dekervel, L Deschutter, D Nittner, E Van Cutsem, C Verslype, J van Pelt
Onco Targets Ther, 2020-07-15;13(0):6907-6916.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma
Authors: ND Jackson, JL Everman, M Chioccioli, L Feriani, KC Goldfarbmu, SP Sajuthi, CL Rios, R Powell, M Armstrong, J Gomez, C Michel, C Eng, SS Oh, J Rodriguez-, P Cicuta, N Reisdorph, EG Burchard, MA Seibold
Cell Rep, 2020-07-07;32(1):107872.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
Authors: J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham
Cell Rep, 2020-06-30;31(13):107820.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy
Authors: Y Kubo, K Ishikawa, K Mori, Y Kobayashi, T Nakama, M Arima, S Nakao, T Hisatomi, M Haruta, KH Sonoda, S Yoshida
Sci Rep, 2020-06-09;10(1):9299.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins
Authors: RA Lu, AA Zeki, S Ram-Mohan, N Nguyen, Y Bai, K Chmiel, S Pecic, X Ai, R Krishnan, CC Ghosh
Front Pharmacol, 2020-05-06;11(0):469.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - Dermatopontin, A Novel Adipokine Promoting Adipose Tissue Extracellular Matrix Remodelling and Inflammation in Obesity
Authors: X Unamuno, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán
J Clin Med, 2020-04-09;9(4):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment
Authors: YD Kim, SM Park, HC Ha, AR Lee, H Won, H Cha, S Cho, JM Cho
J Cancer, 2020-04-06;11(14):4059-4072.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System
Authors: YJ Chen, CY Tsai, YM Cheng, SW Nieh, TK Yeh, CP Chen, MH Wang, LH Chou, TY Chiu, L Liu, C Ho, CT Chen, TW Liu
Sci Rep, 2020-02-18;10(1):2838.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway
Authors: V Delprat, C Tellier, C Demazy, M Raes, O Feron, C Michiels
Sci Rep, 2020-01-21;10(1):882.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling
Authors: G Liu, L Yin, X Ouyang, K Zeng, Y Xiao, Y Li
J Cancer, 2020-01-01;11(5):1277-1287.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - Pancreatic cancer-derived small extracellular vesical Ezrin regulates macrophage polarization and promotes metastasis
Authors: YT Chang, HY Peng, CM Hu, SC Huang, SC Tien, YM Jeng
Am J Cancer Res, 2020-01-01;10(1):12-37.
Species: Human
Sample Types: Whole Cell
Applications: Bioassay - Linking the effects of helminth infection, diet and the gut microbiota with human whole-blood signatures
Authors: SC Lee, MS Tang, AV Easton, JC Devlin, LL Chua, I Cho, FM Moy, TF Khang, YAL Lim, P Loke
PLoS Pathog., 2019-12-16;15(12):e1008066.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - Alpha-linolenic acid enhances the phagocytic and secretory functions of alternatively activated macrophages in part via changes to the oxylipin profile
Authors: SD Pauls, LA Rodway, T Winter, CG Taylor, P Zahradka, HM Aukema
Int. J. Biochem. Cell Biol., 2019-12-04;119(0):105662.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
Authors: N Berges, MS Nawaz, T Børresdatt, L Hagen, M Bjørås, JK Laerdahl, I Alseth
PLoS ONE, 2019-11-08;14(11):e0225081.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling
Authors: X Unamuno, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán
Cell. Mol. Immunol., 2019-09-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells
Authors: Y Wu, MM Konaté, J Lu, H Makhlouf, R Chuaqui, S Antony, JL Meitzler, MJ Difilippan, H Liu, A Juhasz, G Jiang, I Dahan, K Roy, JH Doroshow
J. Immunol., 2019-09-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - TNF-α and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes
Authors: S Sugihara, S Sugimoto, K Tachibana, M Kobashi, H Nomura, T Miyake, Y Hirai, O Yamasaki, S Morizane
J. Dermatol. Sci., 2019-08-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - Boiling Histotripsy-induced Partial Mechanical Ablation Modulates Tumour Microenvironment by Promoting Immunogenic Cell Death of Cancers
Authors: KJ Pahk, CH Shin, IY Bae, Y Yang, SH Kim, K Pahk, H Kim, SJ Oh
Sci Rep, 2019-06-21;9(1):9050.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis
Authors: X Qin, M Liu, S Zhang, C Wang, T Zhang
Cytokine, 2019-03-01;117(0):84-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells
Authors: G Cantero-Re, CM Butnaru, N Brouwers, S Mitrovic, MA Valverde, V Malhotra
J. Biol. Chem., 2018-11-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Tumor-associated macrophages derived CCL18 promotes metastasis in squamous cell carcinoma of the head and neck
Authors: L She, Y Qin, J Wang, C Liu, G Zhu, G Li, M Wei, C Chen, G Liu, D Zhang, X Chen, Y Wang, Y Qiu, Y Tian, X Zhang, Y Liu, D Huang
Cancer Cell Int., 2018-08-28;18(0):120.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Proton irradiation orchestrates macrophage reprogramming through NF?B signaling
Authors: G Genard, AC Wera, C Huart, B Le Calve, S Penninckx, A Fattacciol, T Tabarrant, C Demazy, N Ninane, AC Heuskin, S Lucas, C Michiels
Cell Death Dis, 2018-06-27;9(7):728.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition
Authors: SR Kim, JM Lewis, BM Cyrenne, PF Monico, FN Mirza, KR Carlson, FM Foss, M Girardi
Oncotarget, 2018-06-26;9(49):29193-29207.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages
Authors: I Pop?na, A ?bols, L Saul?te, K Pleiko, E Zandberga, K J?kabsons, E Endzeli?š, A Llorente, A Lin?, U Rieksti?a
Cell Commun. Signal, 2018-04-24;16(1):17.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation, Differentiation - IL-13 induces periostin and eotaxin expression in human primary alveolar epithelial cells: Comparison with paired airway epithelial cells
Authors: Y Ito, R Al Mubarak, N Roberts, K Correll, W Janssen, J Finigan, R Mishra, HW Chu
PLoS ONE, 2018-04-19;13(4):e0196256.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages
Authors: EY Huang, JC Chang, HH Chen, CY Hsu, HC Hsu, KL Wu
BMC Cancer, 2018-03-27;18(1):321.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β
Authors: R da Silva A, AK Mehta, L Madge, J Tocker, M Croft
Front Immunol, 2018-03-19;9(0):576.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture - Lipid abnormalities in atopic skin are driven by type 2 cytokines
Authors: E Berdyshev, E Goleva, I Bronova, N Dyjack, C Rios, J Jung, P Taylor, M Jeong, CF Hall, BN Richers, KA Norquest, T Zheng, MA Seibold, DY Leung
JCI Insight, 2018-02-22;3(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - MicroRNA-31 and MicroRNA-155 Are Overexpressed in Ulcerative Colitis and Regulate IL-13 Signaling by Targeting Interleukin 13 Receptor ?-1
Authors: M Gwiggner, RT Martinez-N, SR Whiteoak, VP Bondanese, A Claridge, JE Collins, JRF Cummings, T Sanchez-El
Genes (Basel), 2018-02-13;9(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis
Authors: R Bruen, S Curley, S Kajani, D Crean, ME O'Reilly, MB Lucitt, CG Godson, FC McGillicud, O Belton
Cardiovasc Diabetol, 2017-11-06;16(1):143.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression
Authors: Y Wang, JB Mumm, R Herbst, R Kolbeck, Y Wang
J. Immunol., 2017-09-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - GATA3 regulates FLG and FLG2 expression in human primary keratinocytes
Authors: J Zeitvogel, N Jokmin, S Rieker, I Klug, C Brandenber, T Werfel
Sci Rep, 2017-09-19;7(1):11847.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma
Authors: S Bartel, N Schulz, F Alessandri, AC Schamberge, P Pagel, FJ Theis, K Milger, E Noessner, SM Stick, A Kicic, O Eickelberg, RJ Freishtat, S Krauss-Ets
Sci Rep, 2017-04-06;7(0):46026.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Interferon-? induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps
Authors: BF Wang, PP Cao, ZC Wang, ZY Li, ZZ Wang, J Ma, B Liao, YK Deng, XB Long, K Xu, H Wang, H Wang, M Zeng, X Lu, Z Liu
Allergy, 2017-04-04;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Therapeutic Effect of Novel Single-Stranded RNAi Agent Targeting Periostin in Eyes with Retinal Neovascularization
Authors: T Nakama, S Yoshida, K Ishikawa, Y Kubo, Y Kobayashi, Y Zhou, S Nakao, T Hisatomi, Y Ikeda, K Takao, K Yoshikawa, A Matsuda, J Ono, S Ohta, K Izuhara, A Kudo, KH Sonoda, T Ishibashi
Mol Ther Nucleic Acids, 2017-02-09;6(0):279-289.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Development of Combining of Human Bronchial Mucosa Models with XposeALI? for Exposure of Air Pollution Nanoparticles
Authors: J Ji, A Hedelin, M Malml”f, V Kessler, G Seisenbaev, P Gerde, L Palmberg
PLoS ONE, 2017-01-20;12(1):e0170428.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Structural Characterisation Reveals Mechanism of IL-13 Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13R?1 and IL-13R?2
Authors: B Popovic
J. Mol. Biol, 2016-12-09;0(0):.
Applications: Bioassay - Classical and alternative macrophages have impaired function during acute and chronic HIV-1 infection
Authors: Leonardo J Galvão-Lim
Braz J Infect Dis, 2016-11-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models
Authors: Nathalie Castex-Riz
Clin Cosmet Investig Dermatol, 2016-11-10;9(0):421-434.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Increased Interleukin-32 Levels in Obesity Promote Adipose Tissue Inflammation and Extracellular Matrix Remodeling: Effect of Weight Loss
Authors: Victoria Catalán
Diabetes, 2016-09-14;65(12):3636-3648.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Thymic stromal chemokine TSLP acts through Th2 cytokine production to induce cutaneous T cell lymphoma
Cancer Res, 2016-09-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE
Authors: Edaire Cheng
PLoS ONE, 2016-06-16;11(6):e0157376.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics
Authors: S O'Reilly, M Ciechomska, N Fullard, S Przyborski, JM van Laar
Sci Rep, 2016-04-26;6(0):25066.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Long-Acting Beta Agonists Enhance Allergic Airway Disease.
Authors: Knight J, Mak G, Shaw J, Porter P, McDermott C, Roberts L, You R, Yuan X, Millien V, Qian Y, Song L, Frazier V, Kim C, Kim J, Bond R, Milner J, Zhang Y, Mandal P, Luong A, Kheradmand F, McMurray J, Corry D
PLoS ONE, 2015-11-25;10(11):e0142212.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1.
Authors: Shipkowski K, Taylor A, Thompson E, Glista-Baker E, Sayers B, Messenger Z, Bauer R, Jaspers I, Bonner J
PLoS ONE, 2015-06-19;10(6):e0128888.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media.
Authors: Lee J, Komatsu K, Lee B, Miyata M, O'Neill Bohn A, Xu H, Yan C, Li J
J Immunol, 2015-05-13;194(12):5990-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model.
Authors: Yao, Xiujuan, Wang, Wei, Li, Yan, Huang, Ping, Zhang, Qian, Wang, Jingjing, Wang, Wen, Lv, Zhe, An, Yunqing, Qin, Jianguo, Corrigan, Chris J, Huang, Kewu, Sun, Yongchan, Ying, Sun
Respir Res, 2015-03-18;16(0):39.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - SOCS3 silencing attenuates eosinophil functions in asthma patients.
Authors: Zafra M, Canas J, Mazzeo C, Gamez C, Sanz V, Fernandez-Nieto M, Quirce S, Barranco P, Ruiz-Hornillos J, Sastre J, del Pozo V
Int J Mol Sci, 2015-03-10;16(3):5434-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium.
Authors: Xu J, Singhera G, Dorscheid D
Respir Res, 2015-02-15;16(0):26.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization - Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.
Authors: Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C
Respir Res, 2015-02-07;16(0):14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
Authors: Herova M, Schmid M, Gemperle C, Hersberger M
J Immunol, 2015-01-30;194(5):2330-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - IL-27 and type 2 immunity in asthmatic patients: association with severity, CXCL9, and signal transducer and activator of transcription signaling.
Authors: Xie M, Mustovich A, Jiang Y, Trudeau J, Ray A, Ray P, Hu H, Holguin F, Freeman B, Wenzel S
J Allergy Clin Immunol, 2014-10-11;135(2):386-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Origin of myofibroblasts in the fibrotic liver in mice.
Authors: Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris T, Park T, Liu X, Xu J, Wang P, Paik Y, Meng F, Asagiri M, Murray L, Hofmann A, Iida T, Glass C, Brenner D, Kisseleva T
Proc Natl Acad Sci U S A, 2014-07-29;111(32):E3297-305.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Proton pump inhibitors decrease eotaxin-3 expression in the proximal esophagus of children with esophageal eosinophilia.
Authors: Park, Jason Y, Zhang, Xi, Nguyen, Nathalie, Souza, Rhonda F, Spechler, Stuart J, Cheng, Edaire
PLoS ONE, 2014-07-02;9(7):e101391.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa.
Authors: Melum G, Farkas L, Scheel C, Van Dieren B, Gran E, Liu Y, Johansen F, Jahnsen F, Baekkevold E
J Allergy Clin Immunol, 2014-06-21;134(3):613-621.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - IL-33 stimulates CXCL8/IL-8 secretion in goblet cells but not normally differentiated airway cells.
Authors: Tanabe T, Shimokawaji T, Kanoh S, Rubin B
Clin Exp Allergy, 2014-04-01;44(4):540-52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma.
Authors: Voraphani N, Gladwin M, Contreras A, Kaminski N, Tedrow J, Milosevic J, Bleecker E, Meyers D, Ray A, Ray P, Erzurum S, Busse W, Zhao J, Trudeau J, Wenzel S
Mucosal Immunol, 2014-02-12;7(5):1175-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Absence of a role for interleukin-13 in inflammatory bowel disease.
Authors: Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque S, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza G, MacDonald T
Eur J Immunol, 2014-02-01;44(2):370-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy.
Authors: Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, Kumar M, Rehman R, Tiwari B, Jha K, Barhanpurkar A, Wani M, Roy S, Mabalirajan U, Ghosh B, Agrawal A
EMBO J, 2014-01-15;33(9):994-1010.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2.
Authors: Engstrom A, Erlandsson A, Delbro D, Wijkander J
Int J Oncol, 2013-12-02;44(2):385-92.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expression.
Authors: Otsuka A, Doi H, Egawa G, Maekawa A, Fujita T, Nakamizo S, Nakashima C, Nakajima S, Watanabe T, Miyachi Y, Narumiya S, Kabashima K
J Allergy Clin Immunol, 2013-09-20;133(1):139-46.e1-10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.
Authors: Pellerin L, Henry J, Hsu C, Balica S, Jean-Decoster C, Mechin M, Hansmann B, Rodriguez E, Weindinger S, Schmitt A, Serre G, Paul C, Simon M
J Allergy Clin Immunol, 2013-02-10;131(4):1094-102.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
Authors: Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B
Sci Rep, 2013-01-01;3(0):1540.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages.
Authors: Gemperle C, Schmid M, Herova M, Marti-Jaun J, Wuest S, Loretz C, Hersberger M
PLoS ONE, 2012-11-21;7(11):e50195.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
Authors: Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P
PLoS Biol, 2012-09-25;10(9):e1001395.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
Authors: Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS
PLoS ONE, 2012-04-18;7(4):e34965.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Expression and regulation of CCL15 by human airway smooth muscle cells.
Authors: Joubert P, Lajoie-Kadoch S, Wellemans V, Létuvé S, Tulic MK, Halayko AJ, Hamid Q
Clin. Exp. Allergy, 2011-11-09;42(1):85-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Epigenetic modulation enhances the therapeutic effect of anti-IL-13R alpha2 antibody in human mesothelioma xenografts.
Clin. Cancer Res., 2011-02-28;17(9):2819-29.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids.
Authors: Le TA, Takai T, Kinosh*ta H, Suto H, Ikeda S, Okumura K, Ogawa H
Allergy, 2009-03-27;64(8):1231-2.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.
Authors: Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ
Invest. Ophthalmol. Vis. Sci., 2009-01-17;50(6):2702-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Divergent effects of hypoxia on dendritic cell functions.
Authors: Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A
Blood, 2008-08-11;112(9):3723-34.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.
Authors: Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsush*ta S
Eur. J. Immunol., 2008-04-01;38(4):1012-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay.
Authors: Miller R, Sadhukhan R, Wu C
J. Immunol. Methods, 2008-03-07;334(1):134-41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Expression and regulation of CCR1 by airway smooth muscle cells in asthma.
Authors: Joubert P, Lajoie-Kadoch S, Welman M, Dragon S, Letuvee S, Tolloczko B, Halayko AJ, Gounni AS, Maghni K, Hamid Q
J. Immunol., 2008-01-15;180(2):1268-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells.
Authors: Kato A, Favoreto S, Avila PC, Schleimer RP
J. Immunol., 2007-07-15;179(2):1080-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Allergic airway inflammation inhibits pulmonary antibacterial host defense.
Authors: Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R
J. Immunol., 2006-08-01;177(3):1833-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli.
Authors: Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC
Am. J. Respir. Cell Mol. Biol., 2006-03-16;35(2):165-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus.
Authors: Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE, Leung DY
Immunity, 2006-03-01;24(3):341-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Th2 cytokine response in Major Depressive Disorder patients before treatment.
Authors: Kiryushko D, Pavon L, Novitskaya V, Sandoval-Lopez G, Soroka V, Eugenia Hernandez M, Klingelhofer J, Loria F, Lukanidin E, Estrada I, Berezin V, Perez M, Bock E, Moreno J, Avila U, Leff P, Anton B, Heinze G
J. Neuroimmunol., 2006-02-02;172(1):156-65.
Applications: ELISA (Standard) - Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13.
Authors: Fujitsu Y, f*ckuda K, Kimura K, Seki K, Kumagai N, Nishida T
Invest. Ophthalmol. Vis. Sci., 2005-03-01;46(3):797-802.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells.
Authors: Kahlon KS, Brown C, Cooper LJ, Raubitschek A, Forman SJ, Jensen MC
Cancer Res., 2004-12-15;64(24):9160-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
J. Immunol., 2004-09-01;173(5):3482-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Differential effect of IL-4 and IL-13 on the expression of recombination-activating genes in mature B cells from human peripheral blood.
Authors: Kajiwara K, Shinazawa M, Morishima H, Yanagihara Y
Cell. Immunol., 2004-02-01;227(2):121-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Production of interleukin-13 by human dendritic cells after stimulation with protein allergens is a key factor for induction of T helper 2 cytokines and is associated with activation of signal transducer and activator of transcription-6.
Authors: Bellinghausen I, Brand P, Bottcher I, Klostermann B, Knop J, Saloga J
Immunology, 2003-02-01;108(2):167-76.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Eosinophils express functional IL-13 in eosinophilic inflammatory diseases.
Authors: Schmid-Grendelmeier P, Altznauer F, Fischer B, Bizer C, Straumann A, Menz G, Blaser K, Wuthrich B, Simon HU
J. Immunol., 2002-07-15;169(2):1021-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay - Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
Authors: Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI
Am. J. Physiol. Lung Cell Mol. Physiol., 2002-05-01;282(5):L1049-56.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
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Reviews for Recombinant Human IL-13 Protein
Average Rating: 4.9 (Based on 10 Reviews)
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Recombinant Human IL-13 Protein
By Anonymous on 08/03/2022
Application: Stem/Immune cell maintenance or differentiation
Downregulation of a given gene after IL-13 exposure detected by qPCR. Three independent experiments.
Recombinant Human IL-13 Protein
By Anonymous on 08/03/2022
Application: Flow
Reason for Rating: Great responses after IL-13 exposure by flow cytometry
Control vs. rIL-13 for 6h
Recombinant Human IL-13 Protein
By Anonymous on 08/03/2022
Application: In vitro bioactivity in cell culture
Reason for Rating: Highly recommended!
Detecting target protein expression after 12h
1. Control
2. +10ng/mL IL-13
Recombinant Human IL-13 Protein
By Anonymous on 12/05/2021
Application: Cell adherence junction integrity
Reason for Rating: Human Il-13 was tested for its effect on adherence junction (yellow) integrity in ECs.
Recombinant Human IL-13 Protein
By Anonymous on 08/30/2019
Application: Cell migration/motility
Recombinant Human IL-13 Protein
By Anonymous on 08/16/2019
Application: In vitro bioactivity in cell culture
Reason for Rating: Worked greatly in human PBMC assay
Recombinant Human IL-13 Protein
By Anonymous on 06/09/2019
Application: In vitro bioactivity in cell culture
Reason for Rating: Cells supplied with 20ng/ml IL-4 and 100ng/ml of GM-CSF to differentiate dendritic cells
Recombinant Human IL-13 Protein
By Anonymous on 11/16/2018
Application: CellProlif
Reason for Rating: Cells were supplied with the cytokinetreatments: 50 ng /ml GM-CSF and 10 ng/ ml1 of IL-13 to differentiate DC cells
Recombinant Human IL-13 Protein
By Danlee Enzler on 04/02/2018
Application: In vitro bioactivity in cell culture
Recombinant Human IL-13 Protein
By Anonymous on 01/20/2016
Application: In vitro bioactivity in cell culture
Reason for Rating: IL-13 is a known to phosphorylate STAT-6. In my experiment, fibroblast cells were incubated for 30min and 4hr with IL-13 and then STAT-6 phosphorylation was measured via western blot. IL-13 phosphorylated STAT-6 as expected.
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